Recent Publications (2011 -)
Rodriguez F, Degnan KO, Seidman CE, Mangion JR. Echocardiography and Cardiac MRI in Mutation-Negative Hypertrophic Cardiomyopathy in an Older Patient: A Case Defining the Need for ICD. Echocardiography. 2014 May 10. doi: 10.1111/echo.12614. [Epub ahead of print] | PDF Download
Kurtzwald-Josefson E, Hochhauser E, Bogachenko K, Harun-Khun S, Katz G, Aravot D, Seidman JG, Seidman CE, Eldar M, Shainberg A, Arad M. Alpha blockade potentiates CPVT therapy in calsequestrin-mutant mice. Heart Rhythm. 2014 Aug;11(8):1471-9. PMCID: PMC4108570 [Available on 2015/2/1].
van den Boogaard M, Smemo S, Burnicka-Turek O, Arnolds DE, van de Werken HJ, Klous P, McKean D, Muehlschlegel JD, Moosmann J, Toka O, Yang XH, Koopmann TT, Adriaens ME, Bezzina CR, de Laat W, Seidman C, Seidman JG, Christoffels VM, Nobrega MA, Barnett P, Moskowitz IP. A common genetic variant within SCN10A modulates cardiac SCN5A expression. J Clin Invest. 2014 Apr 1;124(4):1844-52. PMCID: PMC3973109. | PDF Download
Katz G, Shainberg A, Hochauser E, Kurtzwald-Josefson E, Issac A, El-Ani D, Aravot D, Afek A, Seidman JG, Seidman CE, Eldar M, Arad M. The Role of Mutant Protein level in Autosomal Recessive Catecholamine Dependent Polymorphic Ventricular Tachycardia (CPVT2). Biochem Pharmacol. 2013 Dec 1;86(11):1576-83. PMCID: PMC4103182. | PDF Download
Ip JE, Seidman CE, Liu CF, Cheung JW, Thomas G, Markowitz SM, Lerman BB. Conundrum of sudden cardiac death: making sense of missense. Circ Arrhythm Electrophysiol. 2013 Aug 1;6(4):e58-63. | PDF Download
Kurtzwald Josefson E, Hochhauser E, Katz G, Porat E, Seidman JG, Seidman CE, Chepurko Y, Shainberg A, Eldar M, Arad M. Exercise training improves cardiac function and attenuates arrhythmia in CPVT mice. J Appl Physiol. 2012 Oct 4. 2012;113(11):1677-83. PMCID: PMC3774075. | PDF Download
Rajkumar R, Sembrat JC, McDonough B, Seidman CE, Ahmad F. Functional effects of the TMEM43 Ser358Leu mutation in the pathogenesis of arrhythmogenic right ventricular cardiomyopathy. BMC Med Genet. 2012 Mar 29;13(1):21. PMCID: PMC3352248. | PDF Download
Neckar J, Silhavy J, Zidek V, Landa V, Mlejnek P, Simakova M, Seidman JG, Seidman CE, Kazdova L, Klevstig M, Novak F, Vecka M, Papousek F, Houstek J, Drahota Z, Kurtz TW, Kolar F, Pravenec M. CD36 overexpression predisposes to arrhythmias but reduces infarct size in spontaneously hypertensive rats: gene expression profile analysis. Physiol Genomics. 2012 Feb 1;44(2):173-82. PMCID: PMC3289117. | PDF Download
Katz G, Khoury A, Kurtzwald E, Hochauser E, Porat E, Shainberg A, Seidman JG, Seidman CE, Lorber MA, Eldar M, Arad M. Optimizing CPVT therapy in calsequestrin-mutant mice. Heart Rhythm. 2010 Nov;7(11):1676-82. PMCID: PMC4103178. | PDF Download
Alcalai R, Wakimoto H, Arad M, Planer D, Konno T, Wang L, Seidman JG, Seidman CE, Berul C. Prevention of Ventricular Arrhythmia and Calcium Dysregulation in a Catecholaminergic Polymorphic Ventricular Tachycardia Mouse Model Carrying Calsequestrin-2 Mutation. Jour Cardiovasc Electrophysiology. 2011 Mar;22(3):316-324. PMCID: PMC3053436. | PDF Download
Prior Selected Publications (- 2010)
Body SC, Collard CD, Shernan SK, Fox AA, Liu K-Y, Ritchie MD, Perry TE, Muehlschlegel JD, Aranki S, Donahue BS, Pretorius M, Estrada JC, Ellinor PT, Newton-Cheh CH, Seidman CE, Seidman JG, Herman DS, Lichtner P, Meitinger T, Pfeufer A, Kaab S, Brown NJ, Roden DM Darbar D. Variation in the 4q25 Chromosomal Locus predicts Atrial Fibrillation after Coronary Artery Bypass Graft Surgery. Circ Cardiovasc Genet. 2009;2(5):499-506. PMCID: PMC2801871.
Wolf CM, Arad M, Ahmad F, Sanbe A, Bernstein SA, Toka O, Konno T, Morley G, Robbins J, Seidman JG, Seidman CE, Berul CI. Reversibility of PRKAG2 Glycogen-storage cardiomyopathy and electrophysiological manifestations. Circulation. 2008 Jan 15;117(2):144-54. PMCID: PMC2957811.
Song L, Alcalai R, Arad M, Wolf CM, Toka O, Conner DA, Berul CI, Eldar M, Seidman CE, Seidman JG. Calsequestrin 2 (CASQ2) mutations increase expression of calreticulin and ryanodine receptors, causing catecholaminergic polymorphic ventricular tachycardia. J Clin Invest. 2007;117(7):1814-1823.
Wolf CM, Moskowitz IPG, Arno S, Semsarian C, Bernstein SA, Peterson M, Maida M, Morley GE, Fishman G, Berul CI, Seidman CE, Seidman JG. Somatic events modify hypertrophic cardiomyopathy pathology and link hypertrophy to arrhythmia. Proc Natl Acad Sci USA. 2005;102(50):18123-8.
Jumlongras D, Lin JY, Chapra A, Seidman CE, Seidman JG, Maas RL, Olsen BR. A novel missense mutation in the paired domain of PAX9 causes non-syndromic oligodontia missense mutation in the paired domain of PAX9 causes non-syndromic oligodontia. Hum Genet. 2004;114(3):242-9.
Moskowitz, IPG, Pizard A, Patel VV, Bruneau BG, Kim JB, Kupershcmidt S, Roden D, Berul CI, Seidman JG, Seidman CE. The T-box transcription factor TBX5 is required for the patterning and maturation of the murine cardiac conduction system. Development. 2004;131(16):4107-16.
Patel VV, Arad M, Moskowitz IPG, Maguire CT, Branco D, Seidman JG, Seidman CE, Berul CI. Electrophysiological Characterization and Postnatal Development of Ventricular Preexcitation in a Mouse Model of Cardiac Hypertrophy and Wolff-Parkinson-White Syndrome. JACC. 2003;42(5):942-51.
Berul CI, McConnell BK, Wakimoto H, Moskowitz IP, Maguire CT, Semsarian C, Vargas MM, Gehrmann J, Seidman CE, Seidman JG. Ventricular arrhythmia vulnerability in cardiomyopathic mice with homozygous mutant Myosin-binding protein C gene. Circulation. 2001;104(22):2734-9.
Bevilacqua LM, Maguire CT, Seidman JG, Seidman CE, Berul CI. QT dispersion in a myosin heavy chain familial hypertrophic cardiomyopathy mice. Ped Research. 1999;45(5):643-647.
Mehdirad AA, Fatkin D, DiMarco JP, MacRae CA, Seidman JG, Seidman CE, Benson DW. Electrophysiologic characteristics of accessory atrioventricular connections in an inherited form of Wolff-Parkinson-White Syndrome. J Card Electrophysiol. 1999;10(5):630-635.
Gao WD, Perez NG, Seidman CE, Seidman JG, Marbán E. Altered cardiac excitation-contraction coupling in mutant mice with familial hypertrophic cardiomyopathy. JCI. 1999;103:661-666.
Berul CI, Christe ME, Aronovitz MJ, Maguire, Seidman CE, Seidman JG, Mendelsohn ME. Familial hypertrophic cardiomyopathy mice display gender differences in electrophysiological abnormalities. J Interv Card Electrophysiol. 1998;2(1):7-14.
Benson DW, MacRae CA, Vesely MR, Walsh EP, Seidman JG, Seidman CE, Satler CA. A missense mutation in the pore region of HERG causes familial long QT syndrome. Circulation. 1996;93(10):1791-95.
Dans PE, Nevin KL, Seidman CE, McArthur JC, Kariya ST. In‑hospital CPR 25 years later. Why has survival decreased? Southern Medical Journal. 1985;78:1174‑78.