Recent Publications (2011 -)
Ito K, Bick AG, Flannick J, Friedman DJ, Genovese G, Parfenov M, DePalma SR, Gupta N, Gabriel S, Taylor HA, Fox E, Newton-Cheh C, Kathiresan S, Hirshhorn J, Altshuler D,Pollak M, Wilson JG, Seidman JG, Seidman CE. Increased Burden of Cardiovascular Disease in Carriers of APOL1 Genetic Variants. Circ Res. 2014 Feb 28;114(5):845-50. PMCID: PMC3982584. | PDF Download
Flannick J, Beer NL, Bick AG, Agarwala V, Molnes J, Gupta N, Burtt NP, Florez JC, Meigs JB, Taylor H, Lyssenko V, Irgens H, Fox E, Burslem F, Johansson S, Brosnan MJ, Trimmer JK, Newton-Cheh C, Tuomi T, Molven A, Wilson JG, O’Donnell CJ, Kathiresan S, Hirschhorn JN, Njolstad PR, Rolph T, Seidman JG, Gabriel S, Cox DR, Seidman CE, Groop L, Altshuler D. Assessing the phenotypic effects in the general population of rare variants in genes for a dominant Medelian form of diabetes. Nature Genet. 2013 Nov;45(11):1380-5. PMCID: PMC4051627 | PDF Download
Yoshioka J, Chutkow WA, Lee S, Kim JB, Yan J, Tian R, Lindsey ML, Feener EP, Seidman CE, Seidman JG, Lee RT. Deletion of thioredoxin-interacting protein in mice impairs mitochondrial function but protects the myocardium from ischemia-reperfusion injury. J Clin Invest. 2012 Jan 3;122(1):267-79. PMCID: PMC3248280. | PDF Download
Holleboom AG, Karlsson H, Lin RS, Beres TM, Sierts JA, Herman DS, Stroes ES, Aerts JM, Kastelein JJ, Motazacker MM, Dallinga-Thie GM, Levels JH, Zwinderman AH, Seidman JG, Seidman CE, Ljunggren S, Lefeber DJ, Morava E, Wevers RA, Fritz TA, Tabak LA, Lindahl M, Hovingh GK, Kuivenhoven JA. Heterozygosity for a Loss-of-Function Mutation in GALNT2 Improves Plasma Triglyceride Clearance in Man. Cell Metab. 2011 Dec 7;14(6):811-8. PMCID: PMC3523677. | PDF Download
Fox AA, Pretorius M, Liu KY, Collard CD, Perry TE, Shernan SK, De Jager PL, Hafler DA, Herman DS, DePalma SR, Roden DM, Muehlschlegel JD, Donahue BS, Darbar D, Seidman JG, Body SC, Seidman CE. Genome-wide assessment for genetic variants associated with ventricular dysfunction after primary coronary artery bypass graft surgery. PLoS One. 2011;6(9). | PDF Download
Lemaire SA, McDonald ML, Guo DC, Russell L, Miller CC 3rd, Johnson RJ, Bekheirnia MR, Franco LM, Nguyen M, Pyeritz RE, Bavaria JE, Devereux R, Maslen C, Holmes KW, Eagle K, Body SC, Seidman C, Seidman JG, Isselbacher EM, Bray M, Coselli JS, Estrera AL, Safi HJ, Belmont JW, Leal SM, Milewicz DM. Genome-wide association study identifies a susceptibility locus for thoracic aortic aneurysms and aortic dissections spanning FBN1 at 15q21.1. Nat Genet. 2011 Sep 11;43(10):996-1000. PMCID: PMC3244938. | PDF Download
Pravenec M, Zidek V, Landa V, Simakova M, Mlejnek P, Silhavy J, Maxova M, Kazdova L, Seidman JG, Seidman CE, Eminaga S, Gorham J, Wang J, Kurtz TW. Age-related autocrine effects of transgenic resistin in spontaneously hypertensive rats; gene expression profile analysis. Physiol Genomics. 2011;43(7):372-9. Epub 2011 Feb 1. PMCID: PMC3092332. | PDF Download
Prior Selected Publications (- 2010)
Johnson MD, He L, Herman D, Wakim6oto H, Wallace CA, Zidek V, Mlejnek P, Musilova A, Simakova M, Vorlicek J, Kren V, Viklicky O, Qi NR, Wang J, Seidman CE, Seidman J, Kurtz TW, Aitman TJ, Pravenec M. Dissection of Chromosome 18 blood pressure and salt-sensitivity quantitative trait loci in the spontaneously hypertensive rat. Hypertension. 2009; 54(3):639-645. PMCID: PMC4046892.
Fox AA, Collard CD, Shernan SK, Seidman CE, Seidman JG, Liu KY, Muehlschlegel JD, Perry TE, Aranki SF, Lange C, Herman DS, Meitinger T, Lichtner P, Body SC. Natriuretic peptide system gene variants are associated with ventricular dysfunction after coronary artery bypass grafting. Anesthesiology. 2009;110(4):738-47. PMCID: PMC2735337.
Santiago-Sim T, Mathew-Joseph S, Pannu H, Milewicz DM, Seidman CE, Seidman JG, Kim DH. Sequencing of TGF-{beta} Pathway Genes in Familial Cases of Intracranial Aneurysm. Stroke. 2009;40(5):1604-11. PMCID: PMC2678560.
Santiago-Sim T, Depalma SR, Ju KL, McDonough B, Seidman CE, Seidman JG, Kim DH. Genomewide Linkage in a Large Caucasian Family Maps a New Locus for Intracranial Aneurysms to Chromosome 13q. Stroke. 2009;40(3 Suppl):S57-60. PMID: 19064780; Free full text.
Ofir M, Arad M, Porat E, Freimark D, Chepurko Y, Vidne BA, Seidman CE, Seidman JG, Kemp BE, Hochhauser E. Increased glycogen stores due to gamma-AMPK overexpression protects against ischemia and reperfusion damage. Biochem Pharmacol. 2008 Apr 1;75(7):1482-91.
Encinas JA, Wicker LS, Peterson LB, Mukasa A, Teuscher C, Sobel R, Seidman CE, Seidman JG, Kuchroo VK. QTL influencing autoimmune diabetes and encephalomyelitis to map to a 0.15 cM region containing Il2. Nat Genet. 1999;21(2):158-159.
Mathis BJ, Kim SH, Calabrese K, Haas M, Seidman JG, Seidman CE, Pollak MR. A locus for inherited focal segmental glomerulosclerosis maps to chromosome 19q13. Kidney International. 1998;53(2):282-6.
Conner DA, Mathier MA, Mortensen RM, Christe M, Vatner SF, Seidman CE, Seidman JG. b-Arrestin1 knockout mice appear normal but demonstrate altered cardiac responses to b-Adrenergic stimulation. Circ Res. 1997;81(6):1021-1026.
Shovlin CL, Hughes JMB, Scott J, Seidman CE, Seidman JG. Characterization of endoglin and identification of novel mutations in hereditary hemorrhagic telangiectasia. Am J Hum Genet. 1997;61(1):68-79.
Shovlin CL, Kwiatkowski DJ, Hughes JMB, Seidman CE, Seidman JG. Mapping in the D9S59-D9S67 interval on human chromosome 9. Ann Hum Genet. 1995;59:3881-3882.
Zhang W, Zimmer G, Chen J, Ladd DJ, Li E, Alt FW, Wiederrecht G, Cryan J, O’Neill EA, Seidman CE, Abbas AK, Seidman JG. T-cell responses in calcineurin A alpha-deficient mice. J Exp Med. 1996;183(2):413-420.
Hendrickson BA, Conner DA, Ladd DJ, Kendall D, Rindisbacher L, Corthesy B, Max EE, Neutra MR, Seidman CE, Seidman JG. Altered hepatic transport of immunoglobulin A in mice lacking the J chain. J Exp Med. 1995;182:1905-1911. PMCID: PMC2192233
Brown EM, Pollak M, Chou Y-HW, Seidman CE, Seidman JG, Hebert SC. Cloning and functional characterization of extracellular Ca2+-sensing receptors from parathyroid and kidney. Bone. 1995;17(2S):7S-11S.
Brown EM, Pollak M, Chou Y-HW, Seidman CE, Seidman JG, Hebert SC. The cloning of extracellular Ca2+-sensing receptors from parathyroid and kidney: Molecular mechanisms of extracellular Ca2+-sensing. J Nutrition. 1995;125(7S):1965S-1970S.
Shovlin CL, Hughes JMB, Tuddenham EGD, Temperley I, Perembelon YFN, Scott J, Seidman CE, Seidman JG. A gene for hereditary hemorrhagic telangiectasia maps to chromosome 9q3. Nat Genet. 1994;6:205-209.
Izzo NJ, Seidman CE, Collins S, Colucci WS. a‑adrenergic receptor mRNA level is regulated by norepinephrine in rabbit aortic smooth muscle cells. Proc Natl Acad Sci, USA. 1990;87:6268‑6271.